Toll-Like Receptor Pathways in Autoimmune Diseases
نویسندگان
چکیده
منابع مشابه
Toll-Like Receptor Signaling Pathways
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses. During the past decade, the precise mechanisms und...
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Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration,...
متن کاملToll-Like Receptor Signaling in Liver Diseases
1Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA 3Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA 4Malari Program, Seattle Biomedical Research Institute, Seattle, WA 98109, US...
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Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, inclu...
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ژورنال
عنوان ژورنال: Clinical Reviews in Allergy & Immunology
سال: 2015
ISSN: 1080-0549,1559-0267
DOI: 10.1007/s12016-015-8473-z